Anomaly polynomial of E-string theories

We determine the anomaly polynomial of the E-string theory and its higher-rank generalizations, that is, the 6d $\mathcal{N} =(1, 0)$ superconformal theories on the worldvolume of one or multiple M5-branes embedded within the end-of-the-world brane with $E_8$ symmetry.Comment: v2: 16 pages; typos correcte

Like-sign dimuon asymmetry of B0 meson and LFV in SU(5) SUSY GUT with S4 flavor symmetry

The like-sign dimuon charge asymmetry of the $B$ meson, which was reported in the D\O Collaboration, is studied in the SU(5) SUSY GUT model with $S_4$ flavor symmetry. Additional CP violating effects from the squark sector are discussed in $B_s-\bar B_s$ mixing process. The predicted like-sign charge asymmetry is in the 2$\sigma$ range of the combined result of D\O and CDF measurements. Since the SUSY contributions in the quark sector affect to the lepton sector because of the SU(5) GUT relation, two predictions are given in the leptonic processes: (i) both ${\rm BR}(\mu \to e \gamma)$ and the electron EDM are close to the present upper bound, (ii) the decay ratios of $\tau$ decays, $\tau \to \mu\gamma$ and $\tau \to e \gamma$, are related to each other via the Cabibbo angle $\lambda_c$: {\rm BR}(\tau \to e\gamma)/{\rm BR}(\tau \to \mu\gamma)\sime \lambda_c^2. These are testable at future experiments.Comment: 33 pages, 4 figures, a footnote and references are adde

Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp

BACKGROUND: An in vitro electrophysiological assay system, which can assess compound effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential method in the field of drug development and toxicology. METHODS: In this study, high-throughput electrophysiological recordings of human embryonic kidney (HEK 293) cells and Chinese hamster ovary (CHO) cells stably expressing human ether-a-go-go related gene (hERG) were performed utilizing an automated 384-well-patch-clamp system, which records up to 384 cells simultaneously. hERG channel inhibition, which is closely related to a drug-induced QT prolongation and is increasing the risk of sudden cardiac death, was investigated in the high-throughput screening patch-clamp system. RESULTS: In the automated patch-clamp measurements performed here, K(v) currents were investigated with high efficiency. Various hERG channel blockers showed concentration-dependent inhibition, the 50 % inhibitory concentrations (IC(50)) of those blockers were in good agreement with previous reports. CONCLUSIONS: The high-throughput patch-clamp system has a high potential in the field of pharmacology, toxicology, and cardiac physiology, and will contribute to the acceleration of pharmaceutical drug development and drug safety testing